publication . Article . 2016

Microvesicles from brain-extract-treated mesenchymal stem cells improveneurological functions in a rat model of ischemic stroke

Lee, Ji Yong; Kim, Eiru; Choi, Seong-Mi; Kim, Dong-Wook; Kim, Kwang Pyo; Lee, Insuk; Kim, Han-Soo;
Open Access English
  • Published: 09 Sep 2016 Journal: volume 6issn: 2045-2322, eissn: 2045-2322, Copyright policy
  • Publisher: Nature Publishing Group
Abstract
Transplantation of mesenchymal stem cells (MSCs) was reported to improve functional outcomes in a rat model of ischemic stroke, and subsequent studies suggest that MSC-derived microvesicles (MVs) can replace the beneficial effects of MSCs. Here, we evaluated three different MSC-derived MVs, including MVs from untreated MSCs (MSC-MVs), MVs from MSCs treated with normal rat brain extract (NBE-MSC-MVs), and MVs from MSCs treated with stroke-injured rat brain extract (SBE-MSC-MVs), and tested their effects on ischemic brain injury induced by permanent middle cerebral artery occlusion (pMCAO) in rats. NBE-MSC-MVs and SBE-MSC-MVs had significantly greater efficacy tha...
Subjects
free text keywords: Article
64 references, page 1 of 5

Lu D.. Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma 18, 813–819 (2001).11526987 [PubMed]

Edalatmanesh M. A., Bahrami A. R., Hosseini E., Hosseini M. & Khatamsaz S. Neuroprotective effects of mesenchymal stem cell transplantation in animal model of cerebellar degeneration. Neurol Res 33, 913–920 (2011).22080991 [PubMed]

Ng T. K., Fortino V. R., Pelaez D. & Cheung H. S. Progress of mesenchymal stem cell therapy for neural and retinal diseases. World J Stem Cells 6, 111–119 (2014).24772238 [OpenAIRE] [PubMed]

Chen J.. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 73, 778–786 (2003).12 949903 [PubMed]

Wakabayashi K.. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res 88, 1017–1025 (2010).19885863 [PubMed]

Heo J. S.. Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke. Neuroscience 238, 305–318 (2013).23454369 [PubMed]

Mezey E., Chandross K. J., Harta G., Maki R. A. & McKercher S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779–1782 (2000).11099419 [PubMed]

Baglio S. R., Pegtel D. M. & Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 3, 359 (2012).22973239 [OpenAIRE] [PubMed]

Yu B., Zhang X. & Li X. Exosomes derived from mesenchymal stem cells. Int J Mol Sci 15, 4142–4157 (2014).24608926 [OpenAIRE] [PubMed]

Kim H. S.. Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J Proteome Res 11, 839–849 (2012).22148876 [PubMed]

Bruno S.. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20, 1053–1067 (2009).19389847 [OpenAIRE] [PubMed]

Bian S.. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl)92, 387–397 (2014).24337504 [PubMed]

Li T.. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev 22, 845–854 (2013).23002959 [OpenAIRE] [PubMed]

Zhu Y. G.. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells 32, 116–125 (2014).23939814 [OpenAIRE] [PubMed]

Xin H.. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33, 1711–1715 (2013).23963371 [OpenAIRE] [PubMed]

64 references, page 1 of 5
Abstract
Transplantation of mesenchymal stem cells (MSCs) was reported to improve functional outcomes in a rat model of ischemic stroke, and subsequent studies suggest that MSC-derived microvesicles (MVs) can replace the beneficial effects of MSCs. Here, we evaluated three different MSC-derived MVs, including MVs from untreated MSCs (MSC-MVs), MVs from MSCs treated with normal rat brain extract (NBE-MSC-MVs), and MVs from MSCs treated with stroke-injured rat brain extract (SBE-MSC-MVs), and tested their effects on ischemic brain injury induced by permanent middle cerebral artery occlusion (pMCAO) in rats. NBE-MSC-MVs and SBE-MSC-MVs had significantly greater efficacy tha...
Subjects
free text keywords: Article
64 references, page 1 of 5

Lu D.. Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma 18, 813–819 (2001).11526987 [PubMed]

Edalatmanesh M. A., Bahrami A. R., Hosseini E., Hosseini M. & Khatamsaz S. Neuroprotective effects of mesenchymal stem cell transplantation in animal model of cerebellar degeneration. Neurol Res 33, 913–920 (2011).22080991 [PubMed]

Ng T. K., Fortino V. R., Pelaez D. & Cheung H. S. Progress of mesenchymal stem cell therapy for neural and retinal diseases. World J Stem Cells 6, 111–119 (2014).24772238 [OpenAIRE] [PubMed]

Chen J.. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 73, 778–786 (2003).12 949903 [PubMed]

Wakabayashi K.. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res 88, 1017–1025 (2010).19885863 [PubMed]

Heo J. S.. Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke. Neuroscience 238, 305–318 (2013).23454369 [PubMed]

Mezey E., Chandross K. J., Harta G., Maki R. A. & McKercher S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779–1782 (2000).11099419 [PubMed]

Baglio S. R., Pegtel D. M. & Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 3, 359 (2012).22973239 [OpenAIRE] [PubMed]

Yu B., Zhang X. & Li X. Exosomes derived from mesenchymal stem cells. Int J Mol Sci 15, 4142–4157 (2014).24608926 [OpenAIRE] [PubMed]

Kim H. S.. Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J Proteome Res 11, 839–849 (2012).22148876 [PubMed]

Bruno S.. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20, 1053–1067 (2009).19389847 [OpenAIRE] [PubMed]

Bian S.. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl)92, 387–397 (2014).24337504 [PubMed]

Li T.. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev 22, 845–854 (2013).23002959 [OpenAIRE] [PubMed]

Zhu Y. G.. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells 32, 116–125 (2014).23939814 [OpenAIRE] [PubMed]

Xin H.. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 33, 1711–1715 (2013).23963371 [OpenAIRE] [PubMed]

64 references, page 1 of 5
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publication . Article . 2016

Microvesicles from brain-extract-treated mesenchymal stem cells improveneurological functions in a rat model of ischemic stroke

Lee, Ji Yong; Kim, Eiru; Choi, Seong-Mi; Kim, Dong-Wook; Kim, Kwang Pyo; Lee, Insuk; Kim, Han-Soo;