Glutathionylation-Dependence of Na + -K + -Pump Currents Can Mimic Reduced Subsarcolemmal Na + Diffusion

Article, Other literature type English OPEN
Garcia, Alvaro ; Liu, Chia-Chi ; Cornelius, Flemming ; Clarke, Ronald J. ; Rasmussen, Helge H. (2016)
  • Publisher: Elsevier BV
  • Journal: Biophysical Journal, volume 110, issue 5, pages 1,099-1,109 (issn: 0006-3495)
  • Related identifiers: pmc: PMC4788738, doi: 10.1016/j.bpj.2016.01.014
  • Subject: Channels and Transporters | Biophysics

The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular... View more
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