publication . Article . 2017

INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION

T. G. Gryshachova; I. A. Mikhailova; A. V. Struy; S. G. Chephu; N. N. Petrishchev;
Open Access Russian
  • Published: 01 Jan 2017 Journal: Biomedical Photonics (issn: 2413-9432, Copyright policy)
  • Publisher: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
Abstract
The study of mean blood velocity changes in rat mesenteric venules (15–30 µm) due to photoactivation (λ = 532 nm, 0,175 W/cm2, 300 s) of i.v. injected Rose Bengal (17 mg/kg) is represented in the article. Using in vivo biomicroscopy the progressive decrease of mean blood velocity both during the laser irradiation and after it was registered. The calculation of thermal effects in the irradiated part of microvessel due to laser absorption by hemoglobin and Rose Bengal showed the rise of temperature was not exceed 0.2оC as compared to initial level. Thus, thermal effect has nearly no significant influence on microvascular disturbances caused by Rose Bengal photoact...
Subjects
free text keywords: microcirculation, photosensitizer, Rose Bengal, mean blood velocity, Medical technology, R855-855.5, микроциркуляция, фотосенсибилизатор, бенгальский розовый, средняя скорость кровотока, chemistry.chemical_compound, chemistry, Veterinary medicine, Medicine, business.industry, business
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publication . Article . 2017

INFLUENCE OF PHOTOACTIVATED ROSE BENGAL ON MICROCIRCULATION

T. G. Gryshachova; I. A. Mikhailova; A. V. Struy; S. G. Chephu; N. N. Petrishchev;