Dissolving microneedle patches for dermal vaccination

Article OPEN
Leone, M. ; Monkare, J.T. ; Bouwstra, J.A. ; Kersten, G.F.A. (2017)
  • Publisher: Springer US
  • Journal: Pharmaceutical Research, volume 34, issue 11, pages 2,223-2,240 (issn: 0724-8741, eissn: 1573-904X)
  • Related identifiers: pmc: PMC5643353, doi: 10.1007/s11095-017-2223-2
  • Subject: antigen stability | vaccine delivery | skin immunization | dissolving microneedle fabrication | Expert Review | dissolving microneedle characterization
    mesheuropmc: integumentary system

The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems... View more
  • References (113)
    113 references, page 1 of 12

    1. Bal SM, Ding Z, van Riet E, Jiskoot W, Bouwstra JA. Advances in transcutaneous vaccine delivery: do all ways lead to Rome? J Control Release. 2010;148(3):266-82.

    2. Hilleman MR. Vaccines in historic evolution and perspective: a narrative of vaccine discoveries. Vaccine. 2000;18(15):1436-47.

    3. van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release. 2012;161(2):645-55.

    4. Kersten G, Hirschberg H. Needle-free vaccine delivery. Expert Opin Drug Del. 2007;4(5):459-74.

    5. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev. 2012;64(14):1547-68.

    6. Ita K. Transdermal delivery of drugs with microneedles: strategies and outcomes. J Drug Deliv Sci Tec. 2015;29:16-23.

    7. Hegde NR, Kaveri SV, Bayry J. Recent advances in the administration of vaccines for infectious diseases: microneedles as painless delivery devices for mass vaccination. Drug Discov Today. 2011;16(23-24):1061-8.

    8. Hauri AM, Armstrong GL, Hutin YJF. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS. 2004;15(1):7-16.

    9. Engelke L, Winter G, Hook S, Engert J. Recent insights into cutaneous immunization: how to vaccinate via the skin. Vaccine. 2015;33(37):4663-74.

    10. Kaurav M, Minz S, Sahu K, Kumar M, Madan J, Pandey RS. Nanoparticulate mediated transcutaneous immunization: myth or reality. Nanomedicine. 2016;12(4):1063-81.

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