Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis

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Han, Ying ; Yue, Lanzhu ; Wei, Max ; Ren, Xiubao ; Shao, Zonghong ; Zhang, Ling ; Levine, Ross L. ; Epling-Burnette, Pearlie K. (2017)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 12, issue 1 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5279751, doi: 10.1371/journal.pone.0166014
  • Subject: Mouse Models | Animal Models | Signaling cascades | Research Article | Bone Marrow Cells | TGF-beta signaling cascade | Bone Marrow Transplantation | Blood and Lymphatic System Procedures | Collagens | Proteins | Experimental Organism Systems | Cellular Types | Stem Cells | Biology and Life Sciences | Surgical and Invasive Medical Procedures | Signal transduction | Immune Physiology | Spleen | Developmental Biology | Research and Analysis Methods | Physiology | Medicine | Animal Cells | Q | R | Cell biology | Model Organisms | Mesenchymal Stem Cells | Science | Biochemistry | Transplantation | Cell signaling | Fibrosis | Medicine and Health Sciences

Myelofibrosis is an indicator of poor prognosis in myeloproliferative neoplasms (MPNs), but the precise mechanism(s) contributing to extracellular matrix remodeling and collagen deposition in the bone marrow (BM) niche remains unanswered. In this study, we isolated mese... View more
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