VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans

Article English OPEN
Sung Min Han; Hajer El Oussini; Jelena Scekic-Zahirovic; Jack Vibbert; Pauline Cottee; Jeevan K Prasain; Hugo J Bellen; Luc Dupuis; Michael A Miller;

Mutations in VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), two motor neuron diseases that often include alterations in energy metabolism. We have shown that C. elegans and Drosophila neurons secrete a cleavage produ... View more