Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity

Other literature type, Article English OPEN
Fu, Peter P.; Xia, Qingsu; Lin, Ge; Chou, Ming W.;
(2002)
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences (issn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3390/i3090948
  • Subject: Chemistry | Pyrrolizidine alkaloids | QD1-999 | genotoxic mechanism | riddelliine | QH301-705.5 | tumorigenicity | DNA adducts | Biology (General)
    mesheuropmc: endocrine system | complex mixtures | heterocyclic compounds | organic chemicals

Abstract: Plants that contain pyrrolizidine alkaloids are widely distributed in the world. Although pyrrolizidine alkaloids have been shown to be genotoxic and tumorigenic in experimental animals, the mechanisms of actions have not been fully understood. The results of ... View more
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