Lin28a uses distinct mechanisms of binding to RNA and affects positively and negatively miRNA levels

Article English OPEN
Hobor, Fruzsina; Nowak, Jakub Stanislaw; Velasco, Angela; Choudhurry, Nila; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan;
(2017)
  • Related identifiers: doi: 10.1261/rna.059196.116
  • Subject: let-7 | miRNA-9 | Lin28a, let-7, miRNA-9, neuronal differentiation | neuronal differentiation | Lin28a

<br/>Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3’-5’ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the producti... View more