Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life

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Velazquez, Miguel A.; Sheth, Bhavwanti; Smith, Stephanie J.; Eckert, Judith J.; Osmond, Clive; Fleming, Tom P.;
(2018)
  • Publisher: Elsevier Pub. Co
  • Journal: volume 1,864,issue 2,pages590-600issn: 0006-3002, eissn: 1878-2434
  • Related identifiers: pmc: PMC5764225, doi: 10.1016/j.bbadis.2017.11.020
  • Subject: Birth weight | Insulin | DOHaD (developmental origins of health and disease) | Blastocyst | Branched-chain amino acids | Systolic blood pressure | Article

Mouse maternal low protein diet exclusively during preimplantation development (Emb-LPD) is sufficient to programme altered growth and cardiovascular dysfunction in offspring. Here, we use an in vitro model comprising preimplantation culture in medium depleted in insuli... View more
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