Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life

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Velazquez, Miguel A.; Sheth, Bhavwanti; Smith, Stephanie J.; Eckert, Judith J.; Osmond, Clive; Fleming, Tom P.;

Mouse maternal low protein diet exclusively during preimplantation development (Emb-LPD) is sufficient to programme altered growth and cardiovascular dysfunction in offspring. Here, we use an in vitro model comprising preimplantation culture in medium depleted in insuli... View more
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