Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

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Shakibaei, Mehdi; Buhrmann, Constanze; Kraehe, Patricia; Shayan, Parviz; Lueders, Cora; Goel, Ajay;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 9,issue 1 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3880338, doi: 10.1371/journal.pone.0085397
  • Subject: Cancer Treatment | Research Article | Molecular cell biology | Cancer Prevention | DNA repair | Oncology | Epigenetic Therapy | DNA | Cancers and Neoplasms | Cellular Types | Stem Cells | Biology | Gastroenterology and Hepatology | Medicine | Nucleic acids | Drug Research and Development | Basic Cancer Research | Medizin | Q | R | Drugs and Devices | Gastrointestinal Tumors | Science
    • ddc: ddc:610
    mesheuropmc: digestive system diseases

OBJECTIVE: Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC) are capable of... View more
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