Inhibition of PTEN and activation of Akt by menadione

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Yoshikawa, Kyoko; Nigorikawa, Kiyomi; Tsukamoto, Mariko; Tamura, Namiko; Hazeki, Kaoru; Hazeki, Osamu;
  • Publisher: Elsevier B.V.
  • Journal: Biochimica et Biophysica Acta (BBA) - General Subjects,volume 1,770,issue 4,pages687-693 (issn: 0304-4165)
  • Related identifiers: doi: 10.1016/j.bbagen.2006.12.009
  • Subject: Menadione (vitamin K3) | Naphthoquinone | PTEN | Akt | 490

Menadione (vitamin K3) has been shown to activate Erk in several cell lines. This effect has been shown to be due to the activation of EGF receptors (EGFR) as a result of inhibition of some protein tyrosine phosphatases. In the present study, we examined the effects of ... View more
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