Genome-wide association and functional follow-up reveals new loci for kidney function

Collection, Article English OPEN
Pattaro, Cristian; Köttgen, Anna; Teumer, Alexander; Garnaas, Maija; Böger, Carsten A; Fuchsberger, Christian; Olden, Matthias; Chen, Ming-Huei; Tin, Adrienne; Taliun, Daniel; Li, Man; Gao, Xiaoyi; Gorski, Mathias; Yang, Qiong; Hundertmark, Claudia; Foster, Meredith C; O'Seaghdha, Conall M; Glazer, Nicole; Isaacs, Aaron; Liu, Ching-Ti; Smith, Albert V; O'Connell, Jeffrey R; Struchalin, Maksim; Tanaka, Toshiko; Li, Guo; Johnson, Andrew D; Gierman, Hinco J; Feitosa, Mary; Hwang, Shih-Jen; Atkinson, Elizabeth J; ... view all 51 authors
(2012)
  • Publisher: Figshare
  • Journal: volume 8,issue 3,pagee1002584issn: 1553-7404, eissn: 1553-7404
  • Related identifiers: doi: 10.1371/journal.pgen.1002584
  • Subject: Kidney Failure, Chronic | CARe Consortium | Molecular Biology | /dk/atira/pure/subjectarea/asjc/1100/1105 | CARDIoGRAM Consortium | reveals | Cancer Research | Caspase 9 | kidney | follow-up | fi=Biolääketieteet | en=Biomedicine| | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | /dk/atira/pure/subjectarea/asjc/1300/1312 | DEAD-box RNA Helicases | Animals | loci | Female | 0604 Genetics | African Americans | Wellcome Trust Case Control Consortium 2 (WTCCC2) | Genetics(clinical) | biology | Glomerular Filtration Rate | Developmental Biology | Aged | European Continental Ancestry Group | Ecology, Evolution, Behavior and Systematics | Middle Aged | DNA Helicases | Phosphoric Diester Hydrolases | Medizin | /dk/atira/pure/subjectarea/asjc/2700/2716 | Follow-Up Studies | Gene Knockdown Techniques | Medical Genetics | genome-wide | Cyclin-Dependent Kinases | Medicinsk genetik | Genome-Wide Association Study | /dk/atira/pure/subjectarea/asjc/1300/1306 | Zebrafish | ICBP Consortium | Humans | Male | R1
    • ddc: ddc:610
    mesheuropmc: urologic and male genital diseases

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in associa... View more