Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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Gibson, G.; Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Böger, C. A.; Fuchsberger, C.; Olden, M.; Chen, M.-H.; Tin, A.; Taliun, D.; Li, M.; Gao, X.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, M.C.; O'Seaghdha, C.M.; Glazer, N.; Isaacs, A.; Liu, C.-T.; Smith, A. V.; O'Connell, J.R.; Struchalin, M.; Tanaka, T.; Li, G.; Johnson, A.D.; Gierman, H.J.; Feitosa, M.; Hwang, S.-J.; ... view all 167 authors
(2012)
  • Publisher: PUBLIC LIBRARY SCIENCE
  • Journal: PLOS GENETICS,volume 8,issue 3,pagee1002584 (issn: 1553-7404, eissn: 1553-7404)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pgen.1002584
  • Subject: Kidney Failure, Chronic | CARe Consortium | Molecular Biology | /dk/atira/pure/subjectarea/asjc/1100/1105 | CARDIoGRAM Consortium | reveals | Cancer Research | Caspase 9 | kidney | follow-up | QH426-470 | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | /dk/atira/pure/subjectarea/asjc/1300/1312 | DEAD-box RNA Helicases | Animals | loci | Female | 0604 Genetics | African Americans | Wellcome Trust Case Control Consortium 2 (WTCCC2) | Genetics(clinical) | biology | Glomerular Filtration Rate | Developmental Biology | Aged | European Continental Ancestry Group | Ecology, Evolution, Behavior and Systematics | Middle Aged | DNA Helicases | Phosphoric Diester Hydrolases | /dk/atira/pure/subjectarea/asjc/2700/2716 | Medizin | Follow-Up Studies | Gene Knockdown Techniques | genome-wide | Medical Genetics | Cyclin-Dependent Kinases | Medicinsk genetik | Genome-Wide Association Study | /dk/atira/pure/subjectarea/asjc/1300/1306 | Zebrafish | ICBP Consortium | Humans | Male | R1
    • ddc: ddc:610
    mesheuropmc: urologic and male genital diseases

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in associa... View more