Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

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Bertagnoli, Stéphane ; Gelfi, Jacqueline ; Le Gall, Ghislaine ; Boilletot, Eric ; Vautherot, Jean-François ; Rasschaert, Denis ; Laurent, Sylvie ; Petit, Frédérique ; Boucraut-Baralon, Corine ; Milon, Alain (1996)
  • Publisher: American Society for Microbiology
  • Journal: Journal of virology (issn: 0022-538X)
  • Subject: Research Article | DNA viruses | Leporipoxvirus | Médecine vétérinaire et santé animal | Myxoma virus | Lagovirus | Recombinant vaccines | Experimental infections | Viral infections | RNA viruses | Rabbit diseases | Immune response | Immunity reactions
    mesheuropmc: viruses | cardiovascular system | cardiovascular diseases | animal diseases

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.
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