Cannabidiol Reduces Leukemic Cell Size – But Is It Important?

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Kalenderoglou, Nikoletta; Macpherson, Tara; Wright, Karen L.;

The anti-cancer effect of the plant-derived cannabinoid, cannabidiol, has been widely demonstrated both in vivo and in vitro. However, this body of preclinical work has not been translated into clinical use. Key issues around this failure can be related to narrow dose e... View more
  • References (35)
    35 references, page 1 of 4

    Atkuri K. R. Herzenberg L. A. Niemi A. K. Cowan T. Herzenberg L. A. (2007). Importance of culturing primary lymphocytes at physiological oxygen levels. Proc. Natl. Acad. Sci. U.S.A. 104 4547–4552. 10.1073/pnas.0611732104

    Börner C. Höllt V. Sebald W. Kraus J. (2007). Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids. J. Leukoc. Biol. 81 336–343. 10.1189/jlb.0306224

    Bouaboula M. Rinaldi M. Carayon P. Carillon C. Delpech B. Shire D. (1993). Cannabinoid-receptor expression in human leukocytes. Eur. J. Biochem. 214 173–180. 10.1111/j.1432-1033.1993.tb17910.x

    Daaka Y. Friedman H. Klein T. W. (1996). Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation. J. Pharmacol. Exp. Ther. 276 776–783.

    Dorff T. B. Groshen S. Garcia A. Shah M. Tsao-Wei D. Pham H. (2016). Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer 16:360. 10.1186/s12885-016-2370-6

    Finlay G. J. Wilson W. R. Baguley B. C. (1986). Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukaemia cell lines. Eur. J. Cancer Clin. Oncol. 22 655–662. 10.1016/0277-5379(86)90162-8

    Fowler C. J. (2015). Delta(9)-tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: a critical examination of the preclinical literature. Clin. Pharmacol. Ther. 97 587–596. 10.1002/cpt.84

    Freeburn R. W. Wright K. L. Burgess S. J. Astoul E. Cantrell D. A. Ward S. G. (2002). Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J. Immunol. 169 5441–5450. 10.4049/jimmunol.169.10.5441

    Fumarola C. La Monica S. Alfieri R. R. Borra E. Guidotti G. G. (2005). Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis. Cell Death Discov. 12 1344–1357. 10.1038/sj.cdd.4401660

    Guo C. W. Kawakatsu M. Idemitsu M. Urata Y. Goto S. Ono Y. (2013). Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells. J. Cell. Physiol. 228 2159–2166. 10.1002/jcp.24389

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