publication . Article . 2013

The first modern human dispersals across Africa

Rito, Teresa; Richards, Martin B.; Fernandes, Verónica; Alshamali, Farida; Cerny, Viktor; Pereira, Luísa; Soares, Pedro;
Open Access English
  • Published: 01 Nov 2013 Journal: volume 8, issue 11issn: 1932-6203, eissn: 1932-6203, Copyright policy
  • Publisher: Public Library of Science
Abstract
The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it feasible to test more sophisticated models of early modern human dispersals suggested by mtDNA distributions. Here we have generated 42 novel whole-mtDNA genomes belonging to haplogroup L0, the most divergent clade in the maternal line of descent, and analysed them alongside the growing database of African lineages belonging to L0’s sister clade, L1’6. We propose that the last common ancestor of modern human mtDNAs (carried by “mitochondrial Eve”) possibly arose in central Africa ~180 ka, at a ...
Subjects
free text keywords: Africa, Research Article, Genome Mitochondrial, Evolution, Molecular, Medicine, Q, R, Haplotypes, Population Density, DNA Mitochondrial, Science, Genetics, Population, Human Migration, Phylogeny, Humans
Funded by
FCT| PTDC/CS-ANT/113832/2009
Project
PTDC/CS-ANT/113832/2009
Genetic and chronological characterisation of the European settlement by modern humans in the Upper Palaeolithic
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 113832
  • Funding stream: 5876-PPCDTI
,
FCT| SFRH/BD/61342/2009
Project
SFRH/BD/61342/2009
THE FIRST STOP OF THE MODERN HUMAN MIGRATION OUT-OF-AFRICA (75,000-60,000 YEARS AGO): HIGH-RESOLUTION CHARACTERIZATION OF INFORMATIVE MITOCHONDRIAL DNA, Y-CHROMOSOME AND AUTOSOMAL MARKERS IN THE ARABIAN PENINSULA AND NEAR EAST
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/61342/2009
  • Funding stream: SFRH | Doutoramento
,
FCT| SFRH/BPD/64233/2009
Project
SFRH/BPD/64233/2009
COMPLETE MTDNA GENOME ANALYSIS AND THE MODERN HUMAN SETTLEMENT OF ANATOLIA
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BPD/64233/2009
  • Funding stream: SFRH | Pós-Doutoramento
92 references, page 1 of 7

1. Gamble C (2007) Origins and revolutions: human identity in earliest prehistory. Cambridge University Press.

2. Stringer C (2011) The origin of our species: Penguin.

3. McDougall I, Brown FH, Fleagle JG (2005) Stratigraphic placement and age of modern humans from Kibish, Ethiopia. Nature 433: 733-736. doi: 10.1038/nature03258. PubMed: 15716951.

4. Clark JD, Beyene Y, WoldeGabriel G, Hart WK, Renne PR et al. (2003) Stratigraphic, chronological and behavioural contexts of Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423: 747-752. doi: 10.1038/nature01670. PubMed: 12802333.

5. White TD, Asfaw B, DeGusta D, Gilbert H, Richards GD et al. (2003) Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423: 742-747. doi:10.1038/nature01669. PubMed: 12802332.

6. Barham L, Mitchell P (2008) The first Africans: African archaeology from the earliest tool makers to most recent foragers. Cambridge: Cambridge University Press.

7. Smith TM, Tafforeau P, Reid DJ, Grün R, Egginsll S et al. (2007) Earliest evidence of modern human life history in North African early Homo sapiens. Proc Natl Acad Sci U_S_A 104: 6128-6133. doi: 10.1073/pnas.0700747104. PubMed: 17372199.

8. Shea JJ (2007) The boulevard of broken dreams: evolutionary discontinuity in the Late Pleistocene Levant. In: P MellarsK BoyleO BarYosefC Stringer. The human revolution revisited. Cambridge: Mcdonald Institute Archaeological Publications. pp. 219-232.

9. Millard AR (2008) A critique of the chronometric evidence for hominid fossils: I. Africa and the Near East 500-50ka. J Hum Evol 54: 848-874. doi:10.1016/j.jhevol.2007.11.002. PubMed: 18201747.

10. Rightmire GP, Deacon HJ, Schwartz JH, Tattersall I (2006) Human foot bones from Klasies River main site, South Africa. J Hum Evol 50: 96-103. doi:10.1016/j.jhevol.2005.08.010. PubMed: 16242755.

11. Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A et al. (2009) The genetic structure and history of Africans and African Americans. Science 324: 1035-1044. doi:10.1126/science.1172257. PubMed: 19407144. [OpenAIRE]

12. Henn BM, Gignoux CR, Jobin M, Granka JM, Macpherson JM et al. (2011) Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U_S_A 108: 5154-5162. doi:10.1073/pnas.1017511108. PubMed: 21383195. [OpenAIRE]

13. Veeramah KR, Wegmann D, Woerner A, Mendez FL, Watkins JC et al. (2012) An Early Divergence of KhoeSan Ancestors from Those of Other Modern Humans Is Supported by an ABC-Based Analysis of Autosomal Resequencing Data. Mol Biol Evol 29: 617-630. doi: 10.1093/molbev/msr212. PubMed: 21890477.

14. Gronau I, Hubisz MJ, Gulko B, Danko CG, Siepel A (2011) Bayesian inference of ancient human demography from individual genome sequences. Nat Genet 43: 1031-U1151. doi:10.1038/ng.937. PubMed: 21926973.

15. Schlebusch CM, Skoglund P, Sjödin P, Gattepaille LM, Hernandez D et al. (2012) Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History. Science 338: 374-379. doi: 10.1126/science.1227721. PubMed: 22997136. [OpenAIRE]

92 references, page 1 of 7
Abstract
The emergence of more refined chronologies for climate change and archaeology in prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it feasible to test more sophisticated models of early modern human dispersals suggested by mtDNA distributions. Here we have generated 42 novel whole-mtDNA genomes belonging to haplogroup L0, the most divergent clade in the maternal line of descent, and analysed them alongside the growing database of African lineages belonging to L0’s sister clade, L1’6. We propose that the last common ancestor of modern human mtDNAs (carried by “mitochondrial Eve”) possibly arose in central Africa ~180 ka, at a ...
Subjects
free text keywords: Africa, Research Article, Genome Mitochondrial, Evolution, Molecular, Medicine, Q, R, Haplotypes, Population Density, DNA Mitochondrial, Science, Genetics, Population, Human Migration, Phylogeny, Humans
Funded by
FCT| PTDC/CS-ANT/113832/2009
Project
PTDC/CS-ANT/113832/2009
Genetic and chronological characterisation of the European settlement by modern humans in the Upper Palaeolithic
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 113832
  • Funding stream: 5876-PPCDTI
,
FCT| SFRH/BD/61342/2009
Project
SFRH/BD/61342/2009
THE FIRST STOP OF THE MODERN HUMAN MIGRATION OUT-OF-AFRICA (75,000-60,000 YEARS AGO): HIGH-RESOLUTION CHARACTERIZATION OF INFORMATIVE MITOCHONDRIAL DNA, Y-CHROMOSOME AND AUTOSOMAL MARKERS IN THE ARABIAN PENINSULA AND NEAR EAST
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BD/61342/2009
  • Funding stream: SFRH | Doutoramento
,
FCT| SFRH/BPD/64233/2009
Project
SFRH/BPD/64233/2009
COMPLETE MTDNA GENOME ANALYSIS AND THE MODERN HUMAN SETTLEMENT OF ANATOLIA
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: SFRH/BPD/64233/2009
  • Funding stream: SFRH | Pós-Doutoramento
92 references, page 1 of 7

1. Gamble C (2007) Origins and revolutions: human identity in earliest prehistory. Cambridge University Press.

2. Stringer C (2011) The origin of our species: Penguin.

3. McDougall I, Brown FH, Fleagle JG (2005) Stratigraphic placement and age of modern humans from Kibish, Ethiopia. Nature 433: 733-736. doi: 10.1038/nature03258. PubMed: 15716951.

4. Clark JD, Beyene Y, WoldeGabriel G, Hart WK, Renne PR et al. (2003) Stratigraphic, chronological and behavioural contexts of Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423: 747-752. doi: 10.1038/nature01670. PubMed: 12802333.

5. White TD, Asfaw B, DeGusta D, Gilbert H, Richards GD et al. (2003) Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423: 742-747. doi:10.1038/nature01669. PubMed: 12802332.

6. Barham L, Mitchell P (2008) The first Africans: African archaeology from the earliest tool makers to most recent foragers. Cambridge: Cambridge University Press.

7. Smith TM, Tafforeau P, Reid DJ, Grün R, Egginsll S et al. (2007) Earliest evidence of modern human life history in North African early Homo sapiens. Proc Natl Acad Sci U_S_A 104: 6128-6133. doi: 10.1073/pnas.0700747104. PubMed: 17372199.

8. Shea JJ (2007) The boulevard of broken dreams: evolutionary discontinuity in the Late Pleistocene Levant. In: P MellarsK BoyleO BarYosefC Stringer. The human revolution revisited. Cambridge: Mcdonald Institute Archaeological Publications. pp. 219-232.

9. Millard AR (2008) A critique of the chronometric evidence for hominid fossils: I. Africa and the Near East 500-50ka. J Hum Evol 54: 848-874. doi:10.1016/j.jhevol.2007.11.002. PubMed: 18201747.

10. Rightmire GP, Deacon HJ, Schwartz JH, Tattersall I (2006) Human foot bones from Klasies River main site, South Africa. J Hum Evol 50: 96-103. doi:10.1016/j.jhevol.2005.08.010. PubMed: 16242755.

11. Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A et al. (2009) The genetic structure and history of Africans and African Americans. Science 324: 1035-1044. doi:10.1126/science.1172257. PubMed: 19407144. [OpenAIRE]

12. Henn BM, Gignoux CR, Jobin M, Granka JM, Macpherson JM et al. (2011) Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U_S_A 108: 5154-5162. doi:10.1073/pnas.1017511108. PubMed: 21383195. [OpenAIRE]

13. Veeramah KR, Wegmann D, Woerner A, Mendez FL, Watkins JC et al. (2012) An Early Divergence of KhoeSan Ancestors from Those of Other Modern Humans Is Supported by an ABC-Based Analysis of Autosomal Resequencing Data. Mol Biol Evol 29: 617-630. doi: 10.1093/molbev/msr212. PubMed: 21890477.

14. Gronau I, Hubisz MJ, Gulko B, Danko CG, Siepel A (2011) Bayesian inference of ancient human demography from individual genome sequences. Nat Genet 43: 1031-U1151. doi:10.1038/ng.937. PubMed: 21926973.

15. Schlebusch CM, Skoglund P, Sjödin P, Gattepaille LM, Hernandez D et al. (2012) Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History. Science 338: 374-379. doi: 10.1126/science.1227721. PubMed: 22997136. [OpenAIRE]

92 references, page 1 of 7
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2013

The first modern human dispersals across Africa

Rito, Teresa; Richards, Martin B.; Fernandes, Verónica; Alshamali, Farida; Cerny, Viktor; Pereira, Luísa; Soares, Pedro;