S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway

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Wu, Wei-Jun; Jia, Wan-Wan; Liu, Xin-Hua; Pan, Li-Long; Zhang, Qiu-Yan; Yang, Di; Shen, Xiao-Yan; Liu, Liang; Zhu, Yi Zhun;
(2016)
  • Publisher: Elsevier
  • Journal: Redox Biology,volume 10,pages157-167 (issn: 2213-2317, eissn: 2213-2317)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.redox.2016.08.011, pmc: PMC5066299
  • Subject: HO-1, heme oxygenase-1 | GSH, glutathione | Nuclear factor erythroid-2-related factor 2 | LAT1, L-type amino acid transporter-1 | ICAM-1, intercellular adhesion molecule 1 | PAG, DL-propargylglycine | FLS, fibroblast-like synoviocytes | SPRC, S-propargyl-cysteine | GSSH, oxidized glutathione | ROS, reactive oxygen species | CSE, cystathionine γ-synthase | ARE, antioxidant response element | S-propargyl-cysteine | Research Paper | MMP9, matrix metalloproteinase 9 | R5-920 | Cystathionine γ-synthase | AIA, adjuvant-induced arthritis | Keap1, kelch-like ECH-associated protein 1 | COX-2, cyclooxygenase 2 | BCH, 2-aminobicyclo-2(2,2,1)-heptane-2-caboxylic acid | QH301-705.5 | SOD1, superoxide dismutase 1 | Arthritis | Medicine (General) | iNOS, nitric oxide synthase | Nrf2, nuclear factor erythroid-2-related factor 2 | Biology (General)

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder. Hydrogen sulfide (H2S), the third physiological gasotransmitter, is well recognized as an anti-inflammatory mediator in various inflammatory conditions. Herein, we explored the protective effects o... View more
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