Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

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Hall, Jessica H.; Wiseman, Frances K.; Fisher, Elizabeth M.C.; Tybulewicz, Victor L.J.; Harwood, John L.; Good, Mark A.;
(2016)
  • Publisher: Elsevier BV
  • Journal: Neurobiology of learning and memory,volume 130,pages118-128 (issn: 1074-7427, eissn: 1095-9564)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4898594, doi: 10.1016/j.nlm.2016.02.002
  • Subject: 17 Psychology And Cognitive Sciences | Memory | Tc1 | Memory, Perirhinal, Recognition, Spatial, Tc1, Trisomy-21 | Recognition | Experimental and Cognitive Psychology | Article | Behavioral Science & Comparative Psychology | Trisomy-21 | 11 Medical And Health Sciences | Behavioral Neuroscience | Perirhinal | Spatial | Cognitive Neuroscience
    mesheuropmc: endocrine system

The present study examined memory function in Tc1 mice, a transchromosomic model of Down syndrome (DS). Tc1 mice demonstrated an unusual delay-dependent deficit in recognition memory. More specifically, Tc1 mice showed intact immediate (30sec), impaired short-term (10-m... View more
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