publication . Article . 2009

Genome-wide association analysis of Framingham Heart Study data for the Genetics Analysis Workshop 16: effects due to medication use

Treva K Rice; Yun Ju Sung; Gang Shi; C Charles Gu; DC Rao;
Open Access English
  • Published: 01 Dec 2009 Journal: BMC Proceedings, volume 3, issue Suppl 7, pages S52-S52 (eissn: 1753-6561, Copyright policy)
  • Publisher: BioMed Central
Abstract
<p>Abstract</p> <p>Problems associated with medication use and the consequent effects on genome-wide association analyses were explored using the Genetic Analysis Workshop 16 Problem 3 data. Lipid phenotypes were simulated in the Framingham Heart Study using several measured variables including causal genes (based on a 500 k SNP panel), smoking, dietary intake, and medication usage. We report a sensitivity analysis of how medication use (which artificially alters lipid values) affects association inferences. Associations were performed for LDL-c under seven different correction schemes: 1) ignore medication use entirely (no correction) and adjust for covariates;...
Subjects
free text keywords: Proceedings, Medicine, R, Science, Q, General Biochemistry, Genetics and Molecular Biology, General Medicine, Heritability, Bioinformatics, Covariate, Clinical trial, Genetics, business.industry, business, Genome-Wide Association Analysis, Use medication, Framingham Heart Study
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Genetic Epidemiology of Blood Pressure Intervention
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01HL072507-04
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| HERITAGE FAMILY STUDY, PHASE 4
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL045670-14
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Sodium Sensitivity and Risk of Hypertension
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL087263-05
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| The Family Blood Pressure Program (Program Data Center)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01HL054473-13
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

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