Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

Article, Other literature type English OPEN
Shin, Andrew C. ; Fasshauer, Martin ; Filatova, Nika ; Grundell, Linus A. ; Zielinski, Elizabeth ; Zhou, Jian-Ying ; Scherer, Thomas ; Lindtner, Claudia ; White, Phillip J. ; Lapworth, Amanda L. ; Ilkayeva, Olga ; Knippschild, Uwe ; Wolf, Anna M. ; Scheja, Ludger ; Grove, Kevin L. ; Smith, Richard D. ; Qian, Wei-Jun ; Lynch, Christopher J. ; Newgard, Christopher B. ; Buettner, Christoph (2014)
  • Publisher: Elsevier BV
  • Journal: Cell Metabolism, volume 20, issue 5, pages 898-909 (issn: 1550-4131)
  • Related identifiers: doi: 10.1016/j.cmet.2014.09.003, pmc: PMC4254305
  • Subject: Molecular Biology | Cell Biology | Physiology | Article

Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activ... View more
Share - Bookmark