publication . Article . Other literature type . 2014

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

Shin, Andrew C.; Fasshauer, Martin; Filatova, Nika; Grundell, Linus A.; Zielinski, Elizabeth; Zhou, Jian-Ying; Scherer, Thomas; Lindtner, Claudia; White, Phillip J.; Lapworth, Amanda L.; ...
Open Access English
  • Published: 09 Oct 2014 Journal: Cell Metabolism, volume 20, issue 5, pages 898-909 (issn: 1550-4131, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats that insulin dose-dependently lowers plasma BCAA levels through induction of hepatic protein expression and activity of branched-chain α keto-acid dehydrogenase (BCKDH), the rate-limiting enzyme in the BCAA degradation pathway. Selective induction of hypothalamic insulin signaling in rats and genetic modulation of brain insulin receptors in mice demonstrate that brain insulin signaling is a major regulator of BCAA metabolism by inducing hepatic BCKDH. Short-term overfeeding impairs the ability of brain insul...
Subjects
free text keywords: Molecular Biology, Cell Biology, Physiology, Article
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publication . Article . Other literature type . 2014

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

Shin, Andrew C.; Fasshauer, Martin; Filatova, Nika; Grundell, Linus A.; Zielinski, Elizabeth; Zhou, Jian-Ying; Scherer, Thomas; Lindtner, Claudia; White, Phillip J.; Lapworth, Amanda L.; ...