publication . Article . Other literature type . 2017

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4

Collins, Paul J; McCully, Michelle L; Martínez-Muñoz, Laura; Santiago, César; Wheeldon, James; Caucheteux, Stephan; Thelen, Sylvia; Cecchinato, Valentina; Laufer, Julia M; Purvanov, Vladimir; ...
Open Access English
  • Published: 30 Mar 2017
  • Publisher: HAL CCSD
Abstract
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis. CXCL14 is a homeostatic chemokine with unknown receptor selectivity and preferential expression in peripheral tissues. Here, we demonstrate that CXCL14 synergized with CXCL12 in the induction of chemokine responses in primary human lymphoid cells and cell lines that express CXCR4. Combining subactive concentrations of CXCL12 with 100–300 nM CXCL14 resulted in chemotaxis responses that exceeded maximal responses that were obtained with CXCL12 alone. CXC...
Subjects
free text keywords: signal transduction, synergism, CXCR4, allosteric receptor modulation, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Research, Biotechnology, Genetics, Biochemistry, Molecular Biology, CCL21, CXCL14, CCL17, Cell biology, XCL2, CXC chemokine receptors, Chemokine receptor, Biology, CXCL2, C-C chemokine receptor type 6, ddc:570
Funded by
SNSF| Impact of Synergy-inducing Molecules on Chemokine Activities
Project
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: 31003A_143718
  • Funding stream: Project funding | Project funding (Div. I-III)
,
SNSF| Energy and Electron Transfer Reactions in Heterogeneous Systems
Project
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: 2000-041968
  • Funding stream: Project funding | Project funding (Div. I-III)
,
RCUK| The role of CCR8 in cutaneous vaccination
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: MR/L018284/1
  • Funding stream: MRC

Downloaded from www.fasebj.org to IP 131.251.254.229. The FASEB Journal Vol.31,  No.7 , pp:3084-3097, September, 2017

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