A novel and efficient gene transfer strategy reduces glial reactivity and improves neuronal survival and axonal growth in vitro
Giménez y Ribotta, Minerva
Privát, Alain M.
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Research Article | Neuroscience/Neurobiology of Disease and Regeneration | Cell Biology/Cytoskeleton | Medicine | Genetics and Genomics/Gene Therapy | Q | R | Science | Neurological Disorders/Spinal Disorders | Cell Biology/Neuronal and Glial Cell Biology | Neuroscience/Neuronal and Glial Cell Biology | Molecular Biology/Post-Translational Regulation of Gene Expression
mesheuropmc: nervous system | macromolecular substances
Background: The lack of axonal regeneration in the central nervous system is attributed among other factors to the formation of a glial scar. This cellular structure is mainly composed of reactive astrocytes that overexpress two intermediate filament proteins, the glial...