A novel and efficient gene transfer strategy reduces glial reactivity and improves neuronal survival and axonal growth in vitro

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Mathieu Desclaux; Marisa Teigell; Lahouari Amar; Roland Vogel; Minerva Gimenez Y Ribotta; Alain Privat; Jacques Mallet;
  • Publisher: Public Library of Science
  • Journal: volume 4,issue 7issn: 1932-6203, eissn: 1932-6203
  • Publisher copyright policies & self-archiving
  • Related identifiers: handle: 10261/59193, doi: 10.1371/journal.pone.0006227, pmc: PMC2705675
  • Subject: Research Article | Neuroscience/Neurobiology of Disease and Regeneration | Cell Biology/Cytoskeleton | Medicine | Genetics and Genomics/Gene Therapy | Q | R | Science | Neurological Disorders/Spinal Disorders | Cell Biology/Neuronal and Glial Cell Biology | Neuroscience/Neuronal and Glial Cell Biology | Molecular Biology/Post-Translational Regulation of Gene Expression
    mesheuropmc: nervous system | macromolecular substances

Background: The lack of axonal regeneration in the central nervous system is attributed among other factors to the formation of a glial scar. This cellular structure is mainly composed of reactive astrocytes that overexpress two intermediate filament proteins, the glial... View more
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