Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

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Hoepfner, Dominic; McNamara, Case W.; Lim, Chek Shik; Studer, Christian; Riedl, Ralph; Aust, Thomas; McCormack, Susan L.; Plouffe, David M.; Meister, Stephan; Schuierer, Sven; Plikat, Uwe; Hartmann, Nicole; Staedtler, Frank; Cotesta, Simona; Schmitt, Esther K.; Petersen, Frank; Supek, Frantisek; Glynne, Richard J.; Tallarico, John A.; Porter, Jeffrey A.; Fishman, Mark C.; Bodenreider, Christophe; Diagana, Thierry T.; Movva, N. Rao; Winzeler, Elizabeth A.;

(2012)

Publisher: Cell Press

Journal: Cell Host & Microbe, volume 11, issue 6, pages 654-663 (issn: 1931-3128, eissn: 1934-6069)

Publisher copyright policies & self-archiving

Identifiers: doi: 10.1016/j.chom.2012.04.015, pmc: PMC3391680
Subject: Molecular Biology | Immunology and Microbiology(all) | Cancer Research | Article

Summary With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections. We screened a natural product library to identify inhibitors of Plasmodium f... View more

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Related Organizations (7)

Novartis Institute For Tropical Diseases	90%
Novartis Institute for Tropical Diseases	90%
Genomics Institute of the Novartis Research Foundation ( GNF ) United States Website url: http://www.gnf.org/	90%
Novartis Institutes for Biomedical Research ( NIBR ) United States Website url: https://www.novartis.com/our-science/novartis-institutes-biomedical-research	89%
Genomics Institute of the Novartis Research Foundation United States Website url: https://www.gnf.nibr.com/	90%
Genomics Institute Of The Novartis Research Foundation	90%
Novartis Pharma AG	90%

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WT| Drug discovery for malaria based on novel drug targets, with the aim to find a one dose cure for Plasmodium faliciparum and a curative modality for Plasmodium vivax.
NIH| Discovery of chemically validated malaria liver stage targets
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