Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

Article English OPEN

Hoepfner, Dominic; McNamara, Case W.; Lim, Chek Shik; Studer, Christian; Riedl, Ralph; Aust, Thomas; McCormack, Susan L.; Plouffe, David M.; Meister, Stephan; Schuierer, Sven; Plikat, Uwe; Hartmann, Nicole; Staedtler, Frank; Cotesta, Simona; Schmitt, Esther K.; Petersen, Frank; Supek, Frantisek; Glynne, Richard J.; Tallarico, John A.; Porter, Jeffrey A.; Fishman, Mark C.; Bodenreider, Christophe; Diagana, Thierry T.; Movva, N. Rao; Winzeler, Elizabeth A.;

(2012)

Publisher: Elsevier BV

Journal: Cell Host & Microbe,volume 11,issue 6,pages654-663 (issn: 1931-3128, eissn: 1934-6069)

Publisher copyright policies & self-archiving

Related identifiers: doi: 10.1016/j.chom.2012.04.015, pmc: PMC3391680
Subject: Molecular Biology | Immunology and Microbiology(all) | Article | Cancer Research

Summary With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections. We screened a natural product library to identify inhibitors of Plasmodium f... View more

References (36)
36 references, page 1 of 4
1
2
3
4
Anke, H.. Metabolic products of microorganisms. 184. On the mode of action of cladosporin. J. Antibiot. (Tokyo). 1979; 32: 952-958
Burrows, J.N., Chibale, K., Wells, T.N.. The state of the art in anti-malarial drug discovery and development. Curr. Top. Med. Chem.. 2011; 11: 1226-1254
Dharia, N.V., Sidhu, A.B., Cassera, M.B., Westenberger, S.J., Bopp, S.E., Eastman, R.T., Plouffe, D., Batalov, S., Park, D.J., Volkman, S.K.. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol.. 2009; 10: R21
Eastman, R.T., Fidock, D.A.. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol.. 2009; 7: 864-874
Gamo, F.J., Sanz, L.M., Vidal, J., de Cozar, C., Alvarez, E., Lavandera, J.L., Vanderwall, D.E., Green, D.V., Kumar, V., Hasan, S.. Thousands of chemical starting points for antimalarial lead identification. Nature. 2010; 465: 305-310
Gelperin, D.M., White, M.A., Wilkinson, M.L., Kon, Y., Kung, L.A., Wise, K.J., Lopez-Hoyo, N., Jiang, L., Piccirillo, S., Yu, H.. Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev.. 2005; 19: 2816-2826
Giaever, G., Shoemaker, D.D., Jones, T.W., Liang, H., Winzeler, E.A., Astromoff, A., Davis, R.W.. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet.. 1999; 21: 278-283
Giaever, G., Chu, A.M., Ni, L., Connelly, C., Riles, L., Veronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., Andre, B.. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002; 418: 387-391
Goodman, C.D., Su, V., McFadden, G.I.. The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol.. 2007; 152: 181-191
Grove, J.F., Pople, M.. The insecticidal activity of some fungal dihydroisocoumarins. Mycopathologia. 1981; 76: 65-67

Related Organizations (7)

Genomics Institute Of The Novartis Research Foundation	90%
Novartis Institute For Tropical Diseases	90%
Genomics Institute of the Novartis Research Foundation United States Website url: https://www.gnf.nibr.com/	90%
Novartis Institutes for Biomedical Research ( NIBR ) United States Website url: https://www.novartis.com/our-science/novartis-institutes-biomedical-research	89%
Novartis Pharma AG	90%
Novartis Institute for Tropical Diseases	90%
Genomics Institute of the Novartis Research Foundation ( GNF ) United States Website url: http://www.gnf.org/	90%

Share - Bookmark

Download from
Europe PubMed Central via PubMed Central (Article, 2012)
BASE (Open Access Aggregator) via BASE (Open Access Aggregator) (Article, 2012)
Elsevier BV/ Cell Host & Microbe
Funded by
WT| Drug discovery for malaria based on novel drug targets, with the aim to find a one dose cure for Plasmodium faliciparum and a curative modality for Plasmodium vivax.
NIH| Discovery of chemically validated malaria liver stage targets
Cite this publication

1bbu	Protein Data Bank
3bju	Protein Data Bank
3e9h	Protein Data Bank