Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag–pol–nef antigen

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Herath, S. ; Le Heron, A. ; Colloca, S. ; Bergin, P. ; Patterson, S. ; Weber, J. ; Tatoud, R. ; Dickson, G. (2015)
  • Publisher: Elsevier Science
  • Journal: Vaccine, volume 33, issue 51, pages 7,283-7,289 (issn: 0264-410X, eissn: 1873-2518)
  • Related identifiers: pmc: PMC4678176, doi: 10.1016/j.vaccine.2015.10.111
  • Subject: Immunology and Microbiology(all) | 06 Biological Sciences | Infectious Diseases | IMMUNITY | Medicine, Research & Experimental | Mouse | HIV | LOAD | TEST-OF-CONCEPT | Adenovirus | PROTEIN | 07 Agricultural And Veterinary Sciences | Molecular Medicine | Research & Experimental Medicine | Immunology | Public Health, Environmental and Occupational Health | DELIVERY | EXPRESSION | Life Sciences & Biomedicine | Immunogenicity | EFFICACY | Article | Vaccine | Vectors | Science & Technology | veterinary(all) | Virology | 11 Medical And Health Sciences | CHALLENGE
    mesheuropmc: viruses | virus diseases

Adenoviruses have been shown to be both immunogenic and efficient at presenting HIV proteins but recent trials have suggested that they may play a role in increasing the risk of HIV acquisition. This risk may be associated with the presence of pre-existing immunity to t... View more
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