A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo.

Article English OPEN
Jonathan S Wall; Angela Williams; Tina Richey; Alan Stuckey; Ying Huang; Craig Wooliver; Sallie Macy; Eric Heidel; Neil Gupta; Angela Lee; Brianna Rader; Emily B Martin; Stephen J Kennel;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 8,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3672142, doi: 10.1371/journal.pone.0066181
  • Subject: Chemistry | Animal Models | SPECT imaging | Research Article | Biology | Nuclear medicine | Neuroscience | Radiology | Medicine | Neuroimaging | Protein Structure | Mouse | Radiopharmaceuticals | Q | R | Model Organisms | Radionuclide imaging | Proteins | Biochemistry | Science | Radiochemistry | Radioactivity

Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer’s disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis and can define treat... View more
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