A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo.
Jonathan S Wall; Angela Williams; Tina Richey; Alan Stuckey; Ying Huang; Craig Wooliver; Sallie Macy; Eric Heidel; Neil Gupta; Angela Lee; Brianna Rader; Emily B Martin; Stephen J Kennel;
- Publisher: Public Library of Science (PLoS)
- Journal: PLoS ONE,volume 8,issue 6 (issn: 1932-6203, eissn: 1932-6203)
Related identifiers: ,
- Subject: Chemistry | Animal Models | SPECT imaging | Research Article | Biology | Nuclear medicine | Neuroscience | Radiology | Medicine | Neuroimaging | Protein Structure | Mouse | Radiopharmaceuticals | Q | R | Model Organisms | Radionuclide imaging | Proteins | Biochemistry | Science | Radiochemistry | Radioactivity
Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer’s disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis and can define treat... View more