Epigenetic regulation of histone modifications and Gata6 gene expression induced by maternal diet in mouse embryoid bodies in a model of developmental programming

Article English OPEN
Sun, Congshan; Denisenko, Oleg; Sheth, Bhavwanti; Cox, Andy; Lucas, Emma S; Smyth, Neil R; Fleming, Tom P;
  • Publisher: Springer Nature
  • Journal: BMC Developmental Biology,volume 15,page3 (issn: 1471-213X, eissn: 1471-213X)
  • Related identifiers: doi: 10.1186/s12861-015-0053-1, pmc: PMC4305257
  • Subject: Research Article | Mouse blastocyst | Gata6 | Developmental Biology | Primitive endoderm | Metabolic disease | Embryoid body | Histone epigenetics | Maternal low protein diet | Chromatin immunoprecipitation

Background: dietary interventions during pregnancy alter offspring fitness. We have shown mouse maternal low protein diet fed exclusively for the preimplantation period (Emb-LPD) before return to normal protein diet (NPD) for the rest of gestation, is sufficient to caus... View more
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