Electrochemical Studies of Camptothecin and Its Interaction with Human Serum Albumin

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Zhao, Jing; Zheng, Xiaofeng; Xing, Wei; Huang, Junyi; Li, Genxi;
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences, volume 8, issue 1, pages 42-50 (issn: 1422-0067, eissn: 1422-0067)
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  • Related identifiers: doi: 10.3390/i8010042, pmc: PMC3662986
  • Subject: Chemistry | QD1-999 | QH301-705.5 | Camptothecin | cyclic voltammetry | human serum albumin | Articles | Biology (General)
    mesheuropmc: biological phenomena, cell phenomena, and immunity | body regions | embryonic structures | polycyclic compounds | heterocyclic compounds

Camptothecin, an anticancer component from Camptotheca acuminate, may interact with human serum albumin (HSA) at the subdomain IIA (site I), and then convert to its inactive form(carboxylate form). In this paper, the detailed electrochemical behaviors of camptothecin at... View more
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