MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy

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Zanchi, Cristina; Macconi, Daniela; Trionfini, Piera; Tomasoni, Susanna; Rottoli, Daniela; Locatelli, Monica; Rudnicki, Michael; Vandesompele, Jo; Mestdagh, Pieter; Remuzzi, Giuseppe; Benigni, Ariela; Zoja, Carlamaria;
(2017)
  • Publisher: Springer Berlin Heidelberg
  • Journal: volume 60,issue 6,pages1,114-1,125issn: 0012-186X 1432-0428, eissn: 1432-0428
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5423990, doi: 10.1007/s00125-017-4248-9
  • Subject: Biology and Life Sciences | EXPRESSION | DIFFERENTIATION | GENE | Internal Medicine | Article | ACID | DEMETHYLATION | Albuminuria | PATHOGENESIS | Zucker diabetic fatty rats | CELLS | Endocrinology, Diabetes and Metabolism | PROTEIN | MIR-184 | Fibrosis | MECHANISMS | Diabetic nephropathy

Aims/hypothesis Renal fibrosis is a common complication of diabetic nephropathy and is a major cause of end-stage renal disease. Despite the suggested link between renal fibrosis and microRNA (miRNA) dysregulation in diabetic nephropathy, the identification of the speci... View more
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