Revealing the Mechanisms of Protein Disorder and N-Glycosylation in CD44-Hyaluronan Binding Using Molecular Simulation

Article English OPEN
Guvench, Olgun (2015)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Immunology, volume 6 (issn: 1664-3224, eissn: 1664-3224)
  • Related identifiers: doi: 10.3389/fimmu.2015.00305, doi: 10.3389/fimmu.2015.00305/full, pmc: PMC4468915
  • Subject: RC581-607 | free energy | hyaluronan | unfolding | Review | glycosylation | binding | inhibition | molecular dynamics | Immunologic diseases. Allergy | Immunology | CD44

The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein. When recombinantly expressed by itself, HABD exists as a globular water-soluble ... View more