Targeting Spare CC Chemokine Receptor 5 (CCR5) as a Principle to Inhibit HIV-1 Entry.

Article, Other literature type English OPEN
Jin, Jun; Colin, Philippe; Staropoli, Isabelle; Lima-Fernandes, Evelyne; Ferret, Cécile; Demir, Arzu; Rogée, Sophie; Hartley, Oliver; Randriamampita, Clotilde; Scott, Mark G H; Marullo, Stefano; Sauvonnet, Nathalie; Arenzana-Seisdedos, Fernando; Lagane, Bernard; Brelot, Anne;
  • Publisher: American Society for Biochemistry and Molecular Biology
  • Related identifiers: doi: 10.1074/jbc.M114.559831, pmc: PMC4081942
  • Subject: HIV-1 | [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology | antiviral agents | [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology | virus entry | endocytosis | conformation | Molecular Bases of Disease | CCR5 | G protein-coupled receptor (GPCR)
    mesheuropmc: viruses | virus diseases

International audience; : CCR5 binds the chemokines CCL3, CCL4, and CCL5 and is the major coreceptor for HIV-1 entry into target cells. Chemokines are supposed to form a natural barrier against human immunodeficiency virus, type 1 (HIV-1) infection. However, we showed t... View more
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