Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides

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Ehley, Jennifer A.; Melander, Christian; Herman, David; Baird, Eldon E.; Ferguson, Heather A.; Goodrich, James A.; Dervan, Peter B.; Gottesfeld, Joel M.;

When targeted to sequences adjacent to a TATA element, pyrrole-imidazole (Py-Im) polyamides inhibit the DNA binding activity of TATA box binding protein (TBP) and basal transcription by RNA polymerase II. In the present study, we scanned the human immunodeficiency virus... View more
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