Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAFV600E: New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment
Duquette, Mark; Sadow, Peter M.; Lawler, Jack; Nucera, Carmelo;
Publisher: Frontiers Media S.A.
Journal: Frontiers in Endocrinology,volume 4 (issn: 1664-2392, eissn: 1664-2392)
Subject: thyroid cancer | Diseases of the endocrine glands. Clinical endocrinology | BRAFV600E | TSP-1 | microenvironment | integrins | RC648-665 | Original Research | BRAF | extracellular matrix | Endocrinology
mesheuropmc: endocrine system | virus diseases
Background and Rationale: Anaplastic thyroid cancer (ATC) is characterized by pleomorphic cells, has a poor prognosis, is highly devastating disease, and is not curable. No reliable biomarkers of metastatic potential, helpful for early diagnosis of ATC and therapeutic r... View more