ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin

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Zhang, Lei; Chen, Xiu-Ping; Qin, He; Jiang, Ling; Qin, Yuan-Han;
  • Publisher: Taylor & Francis
  • Journal: Renal Failure,volume 40,issue 1,pages266-272 (issn: 0886-022X, eissn: 1525-6049)
  • Related identifiers: doi: 10.1080/0886022X.2018.1456459, pmc: PMC6014515
  • Subject: Diseases of the genitourinary system. Urology | RC870-923 | glomerulosclerosis | Laboratory Study | proteinuria | TRPC6 | ATRA
    mesheuropmc: urologic and male genital diseases | urogenital system | neoplasms | organic chemicals | female genital diseases and pregnancy complications

Abstract Objective: In this research, we explored the molecular mechanism of proteinuria in glomerulosclerosis rats and the protective effects of ATRA. Methods: This research set up three groups: SHO group, GS group, and ATRA group (15 mg/(kg d), Sigma, St. Louis, MO). ... View more
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