Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

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Kourtis, Iraklis C.; Hirosue, Sachiko; De Titta, Alexandre; Kontos, Stephan; Stegmann, Toon; Hubbell, Jeffrey A.; Swartz, Melody A.;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 8, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0061646, pmc: PMC3633981
  • Subject: Monocytes | Immunomodulation | Research Article | Biology | Antigen-Presenting Cells | Tumor Immunology | Materials Science | Lymphoid Organs | Immune Cells | Medicine | Nanomaterials | Q | R | Immunologic Subspecialties | Science | Immune System | Nanotechnology | Biomaterials | Immunology | Bionanotechnology

Nanoparticles have been extensively developed for therapeutic and diagnostic applications. While the focus of nanoparticle trafficking in vivo has traditionally been on drug delivery and organ-level biodistribution and clearance, recent work in cancer biology and infect... View more
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