PO2 cycling reduces diaphragm fatigue by attenuating ROS formation.

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Zuo, Li; Diaz, Philip T.; Chien, Michael T.; Roberts, William J.; Kishek, Juliana; Best, Thomas M.; Wagner, Peter D.;
(2014)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 9,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4192541, doi: 10.1371/journal.pone.0109884
  • Subject: Muscle Contraction | Research Article | Molecular Cell Biology | Anatomy | Respiration | Biomechanics | Thoracic Diaphragm | Hypoxia | Biology and Life Sciences | Breathing | Respiratory Physiology | Musculoskeletal System | Physiology | Pulmonary Function | Pulmonology | Medicine | Musculoskeletal Mechanics | Muscle Physiology | Q | R | Cell Biology | Science | Physiological Processes | Medicine and Health Sciences | Oxidative Stress
    mesheuropmc: circulatory and respiratory physiology | respiratory tract diseases | respiratory system | cardiovascular system | inorganic chemicals

Prolonged muscle exposure to low PO2 conditions may cause oxidative stress resulting in severe muscular injuries. We hypothesize that PO2 cycling preconditioning, which involves brief cycles of diaphragmatic muscle exposure to a low oxygen level (40 Torr) followed by a ... View more
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