A unique regulatory phase of DNA methylation in the early mammalian embryo
Smith, Zachary D.
Chan, Michelle M.
Mikkelsen, Tarjei S.
(issn: 0028-0836, eissn: 1476-4687)
Summary DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methyl cytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this m...