A unique regulatory phase of DNA methylation in the early mammalian embryo

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Smith, Zachary D. ; Chan, Michelle M. ; Mikkelsen, Tarjei S. ; Gu, Hongcang ; Gnirke, Andreas ; Regev, Aviv ; Meissner, Alexander (2012)

Summary DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methyl cytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this m... View more