publication . Doctoral thesis . 2016

Implication of replication/transcription interference in cancer development

Promonet, Alexy;
Open Access French
  • Published: 15 Dec 2016
  • Publisher: HAL CCSD
  • Country: France
Genome instability is a hallmark of cancer cells. It has been proposed that at early stages of the cancer process, genomic instability is caused by oncogene-induced replication stress, a poorly-understood process characterized with the accumulation of stalled replication forks and gammaH2AX on chromatin. Understanding the origin of chronic replication stress represents a major challenge in cancer biology. We have previously shown that depletion of DNA Topoisomerase 1 or the splicing factor ASF/SF2 in mammalian cells interferes with replication fork progression, activating the DNA damage response and inducing chromosome breaks (Tuduri et al., 2009). Since DNA dam...
free text keywords: R-Loop, Genomic instability, DNA replication, Checkpoint, Cancer, Point de contrôle, L'instabilité du génome, Réplication, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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