DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation

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Alexandrov, Boian S.; Alexandrov, Ludmil B.; Fukuyo, Yayoi; Bishop, Alan R.; Rasmussen, Kim Ø.; Usheva, Anny; Gelev, Vladimir; Yoo, Sang Wook;

We assess the role of DNA breathing dynamics as a determinant of promoter strength and transcription start site (TSS) location. We compare DNA Langevin dynamic profiles of representative gene promoters, calculated with the extended non-linear PBD model of DNA with exper... View more
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