DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation

Article English OPEN
Alexandrov, Boian S.; Gelev, Vladimir; Yoo, Sang Wook; Alexandrov, Ludmil B.; Fukuyo, Yayoi; Bishop, Alan R.; Rasmussen, Kim Ø.; Usheva, Anny;
  • Publisher: Oxford University Press
  • Journal: Nucleic Acids Research,volume 38,issue 6,pages1,790-1,795 (issn: 0305-1048, eissn: 1362-4962)
  • Related identifiers: pmc: PMC2847213, doi: 10.1093/nar/gkp1084
  • Subject: Gene Regulation, Chromatin and Epigenetics

We assess the role of DNA breathing dynamics as a determinant of promoter strength and transcription start site (TSS) location. We compare DNA Langevin dynamic profiles of representative gene promoters, calculated with the extended non-linear PBD model of DNA with exper... View more
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