publication . Preprint . Research . 2020

Self-reported sleep problems are related to cortical thinning in aging but not memory decline and amyloid-β accumulation – results from the Lifebrain consortium

Fjell, Anders M.; Sørensen, Øystein; Amlien, Inge K.; Bartrés-Faz, David; Brandmaier, Andreas M.; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus P.; ...
Open Access English
  • Published: 28 Apr 2020
  • Publisher: Cold Spring Harbor Laboratory
Abstract
Abstract Background Older persons with poor sleep are more likely to develop neurodegenerative disease, but the causality underlying this association is unclear. To move towards explanation, we examine whether sleep quality and quantity are similarly associated with brain changes across the adult lifespan. Methods Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index;PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n=2205, 4363 MRIs, 18-92 years). Analyses were augmented by considering episodic memory change, gene expression from the Allen Human Brain Atlas, and amyloid-beta (Aβ) a...
Funded by
EC| Lifebrain
Project
Lifebrain
Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts
  • Funder: European Commission (EC)
  • Project Code: 732592
  • Funding stream: H2020 | RIA
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| CONSTRUCTIVEMEM
Project
CONSTRUCTIVEMEM
Emergence and decline of constructive memory – Life-span changes in a common brain network for imagination and episodic memory
  • Funder: European Commission (EC)
  • Project Code: 283634
  • Funding stream: FP7 | SP2 | ERC
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
WT| Wellcome Centre for Integrative Neuroimaging
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 203139
  • Funding stream: Cognitive Neuroscience and Mental Health
Download fromView all 2 versions
bioRxiv
Preprint . 2020
Provider: bioRxiv
MPG.PuRe
Research . 2020
Provider: MPG.PuRe
36 references, page 1 of 3

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Shi, L. et al. Sleep disturbances increase the risk of dementia: A systematic review and metaanalysis. Sleep Med Rev 40, 4-16, doi:10.1016/j.smrv.2017.06.010 (2018).

Hatfield, C. F., Herbert, J., van Someren, E. J., Hodges, J. R. & Hastings, M. H. Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain 127, 1061-1074, doi:10.1093/brain/awh129 (2004).

Videnovic, A., Lazar, A. S., Barker, R. A. & Overeem, S. 'The clocks that time us'--circadian rhythms in neurodegenerative disorders. Nat Rev Neurol 10, 683-693, doi:10.1038/nrneurol.2014.206 (2014).

Prinz, P. N. et al. Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type. Neurobiol Aging 3, 361-370 (1982). [OpenAIRE]

Irwin, M. R. & Vitiello, M. V. Implications of sleep disturbance and inflammation for Alzheimer's disease dementia. Lancet Neurol, doi:10.1016/S1474-4422(18)30450-2 (2019).

Mander, B. A., Winer, J. R., Jagust, W. J. & Walker, M. P. Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease? Trends Neurosci 39, 552-566, doi:10.1016/j.tins.2016.05.002 (2016).

Xu, W., Tan, C. C., Zou, J. J., Cao, X. P. & Tan, L. Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 91, 236-244, doi:10.1136/jnnp-2019-321896 (2020). [OpenAIRE]

Fan, L., Xu, W., Cai, Y., Hu, Y. & Wu, C. Sleep Duration and the Risk of Dementia: A Systematic Review and Meta-analysis of Prospective Cohort Studies. J Am Med Dir Assoc 20, 1480-1487 e1485, doi:10.1016/j.jamda.2019.06.009 (2019).

Bubu, O. M. et al. Sleep, Cognitive impairment, and Alzheimer's disease: A Systematic Review and Meta-Analysis. Sleep 40, doi:10.1093/sleep/zsw032 (2017).

Gerontology 64, 49-57, doi:10.1159/000479508 (2018).

Scullin, M. K. & Bliwise, D. L. Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci 10, 97-137, doi:10.1177/1745691614556680 (2015).

Ohayon, M. M., Carskadon, M. A., Guilleminault, C. & Vitiello, M. V. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27, 1255-1273 (2004). [OpenAIRE]

Mander, B. A., Winer, J. R. & Walker, M. P. Sleep and Human Aging. Neuron 94, 19-36, doi:10.1016/j.neuron.2017.02.004 (2017).

Walhovd, K. B. et al. Healthy minds 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). Eur Psychiatry 50, 47-56, doi:10.1016/j.eurpsy.2017.12.006 (2018).

Carvalho, D. Z. et al. Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults. Sleep Med 32, 236-243, doi:10.1016/j.sleep.2016.08.023 (2017).

36 references, page 1 of 3
Abstract
Abstract Background Older persons with poor sleep are more likely to develop neurodegenerative disease, but the causality underlying this association is unclear. To move towards explanation, we examine whether sleep quality and quantity are similarly associated with brain changes across the adult lifespan. Methods Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index;PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n=2205, 4363 MRIs, 18-92 years). Analyses were augmented by considering episodic memory change, gene expression from the Allen Human Brain Atlas, and amyloid-beta (Aβ) a...
Funded by
EC| Lifebrain
Project
Lifebrain
Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts
  • Funder: European Commission (EC)
  • Project Code: 732592
  • Funding stream: H2020 | RIA
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| CONSTRUCTIVEMEM
Project
CONSTRUCTIVEMEM
Emergence and decline of constructive memory – Life-span changes in a common brain network for imagination and episodic memory
  • Funder: European Commission (EC)
  • Project Code: 283634
  • Funding stream: FP7 | SP2 | ERC
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
WT| Wellcome Centre for Integrative Neuroimaging
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 203139
  • Funding stream: Cognitive Neuroscience and Mental Health
Download fromView all 2 versions
bioRxiv
Preprint . 2020
Provider: bioRxiv
MPG.PuRe
Research . 2020
Provider: MPG.PuRe
36 references, page 1 of 3

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Shi, L. et al. Sleep disturbances increase the risk of dementia: A systematic review and metaanalysis. Sleep Med Rev 40, 4-16, doi:10.1016/j.smrv.2017.06.010 (2018).

Hatfield, C. F., Herbert, J., van Someren, E. J., Hodges, J. R. & Hastings, M. H. Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain 127, 1061-1074, doi:10.1093/brain/awh129 (2004).

Videnovic, A., Lazar, A. S., Barker, R. A. & Overeem, S. 'The clocks that time us'--circadian rhythms in neurodegenerative disorders. Nat Rev Neurol 10, 683-693, doi:10.1038/nrneurol.2014.206 (2014).

Prinz, P. N. et al. Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type. Neurobiol Aging 3, 361-370 (1982). [OpenAIRE]

Irwin, M. R. & Vitiello, M. V. Implications of sleep disturbance and inflammation for Alzheimer's disease dementia. Lancet Neurol, doi:10.1016/S1474-4422(18)30450-2 (2019).

Mander, B. A., Winer, J. R., Jagust, W. J. & Walker, M. P. Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease? Trends Neurosci 39, 552-566, doi:10.1016/j.tins.2016.05.002 (2016).

Xu, W., Tan, C. C., Zou, J. J., Cao, X. P. & Tan, L. Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 91, 236-244, doi:10.1136/jnnp-2019-321896 (2020). [OpenAIRE]

Fan, L., Xu, W., Cai, Y., Hu, Y. & Wu, C. Sleep Duration and the Risk of Dementia: A Systematic Review and Meta-analysis of Prospective Cohort Studies. J Am Med Dir Assoc 20, 1480-1487 e1485, doi:10.1016/j.jamda.2019.06.009 (2019).

Bubu, O. M. et al. Sleep, Cognitive impairment, and Alzheimer's disease: A Systematic Review and Meta-Analysis. Sleep 40, doi:10.1093/sleep/zsw032 (2017).

Gerontology 64, 49-57, doi:10.1159/000479508 (2018).

Scullin, M. K. & Bliwise, D. L. Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci 10, 97-137, doi:10.1177/1745691614556680 (2015).

Ohayon, M. M., Carskadon, M. A., Guilleminault, C. & Vitiello, M. V. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27, 1255-1273 (2004). [OpenAIRE]

Mander, B. A., Winer, J. R. & Walker, M. P. Sleep and Human Aging. Neuron 94, 19-36, doi:10.1016/j.neuron.2017.02.004 (2017).

Walhovd, K. B. et al. Healthy minds 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). Eur Psychiatry 50, 47-56, doi:10.1016/j.eurpsy.2017.12.006 (2018).

Carvalho, D. Z. et al. Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults. Sleep Med 32, 236-243, doi:10.1016/j.sleep.2016.08.023 (2017).

36 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue