publication . Article . Other literature type . 2017

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Kirschner, K; Chandra, T; Kiselev, V; Flores-Santa Cruz, D; Macaulay, IC; Park, HJ; Li, Juan; Kent, David; Kumar, R; Pask, DC; ...
Open Access English
  • Published: 01 May 2017
  • Country: United Kingdom
Abstract
Kirschner et al. describe heterogeneous aging of hematopoietic stem cells (HSCs), with a subset of old HSCs displaying signs of functional exhaustion. An increase in proliferation expands the aged HSC subgroup, linking prolonged proliferation to functional decline in HSCs.
Subjects
free text keywords: Report, aging, scRNA-seq, hematology, JAK2, p53, stem cells, cellular aging, cancer, leukemia, genomics, Biology (General), QH301-705.5, Molecular biology, Transcription factor, Cell cycle, Immunology, Hematopoietic stem cell, medicine.anatomical_structure, medicine, Biology, Cell biology, Janus kinase 2, biology.protein, Cell growth, Transcriptome, Stem cell, stat
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