publication . Article . 2016

Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells

Angeliki Tiptiri-Kourpeti; Katerina Spyridopoulou; Valentina Santarmaki; Georgios Aindelis; Evgenia Tompoulidou; Eleftheria E Lamprianidou; Georgia Saxami; Petros Ypsilantis; Evangeli S Lampri; Constantinos Simopoulos; ...
Open Access English
  • Published: 01 Feb 2016 Journal: PLoS ONE, volume 11, issue 2 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
Abstract
Probiotic microorganisms such as lactic acid bacteria (LAB) exert a number of strain-specific health-promoting activities attributed to their immunomodulatory, anti-inflammatory and anti-carcinogenic properties. Despite recent attention, our understanding of the biological processes involved in the beneficial effects of LAB strains is still limited. To this end, the present study investigated the growth-inhibitory effects of Lactobacillus casei ATCC 393 against experimental colon cancer. Administration of live Lactobacillus casei (as well as bacterial components thereof) on murine (CT26) and human (HT29) colon carcinoma cell lines raised a significant concentrat...
Subjects
free text keywords: Cancer Treatment, Digestive System, Research Article, Gastrointestinal Tract, Bacteria, Cell lines, Anatomy, Staining, Apoptosis, Gut Bacteria, Cell Processes, Oncology, HT29 cells, Lactobacillus, Cancers and Neoplasms, Biology and Life Sciences, Colorectal Cancer, Cell Death, Research and Analysis Methods, Microbiology, Medicine, Specimen Preparation and Treatment, Q, R, Cell Biology, Science, Biological cultures, Organisms, Colon, Cell Staining, Medicine and Health Sciences, Probiotics
69 references, page 1 of 5

1 Rafter J. The effects of probiotics on colon cancer development. Nutr Res Rev. 2004;17: 277–284. doi: 10.1079/NRR200484 19079931 [PubMed]

2 Marco ML, Pavan S, Kleerebezem M. Towards understanding molecular modes of probiotic action. Curr Opin Biotechnol. 2006;17(2): 204–210. 16510275 [PubMed]

3 Zhu Y, Michelle Luo T, Jobin C, Young HA. Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett. 2011;309(2): 119–127. doi: 10.1016/j.canlet.2011.06.004 21741763 [OpenAIRE] [PubMed]

4 Walsh CJ, Guinane CM, O’Toole PW, Cotter PD. Beneficial modulation of the gut microbiota. FEBS Lett. 2014;588(22): 4120–4130. doi: 10.1016/j.febslet.2014.03.035 24681100 [PubMed]

5 Zhong L, Zhang X, Covasa M. Emerging roles of lactic aci d bacteria in protection against colorectal cancer. World J Gastroenterol. 2014;20(24):7878–7886. doi: 10.3748/wjg.v20.i24.7878 24976724 [OpenAIRE] [PubMed]

6 Rauch M, Lynch SV. Probiotic manipulation of the gastrointestinal microbiota. Gut Microbes. 2010;1(5): 335–338. 21327043 [OpenAIRE] [PubMed]

7 Shida K, Nanno M, Nagata S. Flexible cytokine production by macrophages and T cells in response to probiotic bacteria: a possible mechanism by which probiotics exert multifunctional immune regulatory activities. Gut Microbes. 2011;2(2): 109–114. 21637028 [PubMed]

8 Serban DE. Gastrointestinal cancers: influence of gut microbiota, p robiotics and prebiotics. Cancer Lett. (2014);345(2): 258–270. doi: 10.1016/j.canlet.2013.08.013 23981580 [PubMed]

9 Pagnini C, Corleto VD, Mangoni ML, Pilozzi E, Torre MS, Marchese R, et al Alteration of local microflora and α-defensins hyper-production in colonic adenoma mucosa. J Clin Gastroenterol. 2011;45(7): 602–610. doi: 10.1097/MCG.0b013e31820abf29 21346603 [PubMed]

10 Neish AS. The microbiota and colonic neoplasia. An emerging link?J Clin Gastroenterol. 2011;45(7): 571 doi: 10.1097/MCG.0b013e318219221d 21555952 [PubMed]

11 Clevers H. At the crossroads of inflammation and cancer. Cell. 2004;118: 671–674. 15369667 [OpenAIRE] [PubMed]

12 LeBlanc A, LeBlanc J. Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications. World J Gastroenterol. 2014;20(33): 16518–16528.25469019 [OpenAIRE] [PubMed]

13 Oelschlaeger TA. Mechanisms of probiotic actions—A review. Int J Med Microbiol. 2010;300(1): 57–62. doi: 10.1016/j.ijmm.2009.08.005 19783474 [PubMed]

14 Tsilingiri K, Res cigno M. Postbiotics: what else?Benef Microbes. 2013;4(1): 101–107. doi: 10.3920/BM2012.0046 23271068 [OpenAIRE] [PubMed]

15 Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, et al Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011;121(6): 2242–2253. doi: 10.1172/JCI44031 21606592 [OpenAIRE] [PubMed]

69 references, page 1 of 5
Abstract
Probiotic microorganisms such as lactic acid bacteria (LAB) exert a number of strain-specific health-promoting activities attributed to their immunomodulatory, anti-inflammatory and anti-carcinogenic properties. Despite recent attention, our understanding of the biological processes involved in the beneficial effects of LAB strains is still limited. To this end, the present study investigated the growth-inhibitory effects of Lactobacillus casei ATCC 393 against experimental colon cancer. Administration of live Lactobacillus casei (as well as bacterial components thereof) on murine (CT26) and human (HT29) colon carcinoma cell lines raised a significant concentrat...
Subjects
free text keywords: Cancer Treatment, Digestive System, Research Article, Gastrointestinal Tract, Bacteria, Cell lines, Anatomy, Staining, Apoptosis, Gut Bacteria, Cell Processes, Oncology, HT29 cells, Lactobacillus, Cancers and Neoplasms, Biology and Life Sciences, Colorectal Cancer, Cell Death, Research and Analysis Methods, Microbiology, Medicine, Specimen Preparation and Treatment, Q, R, Cell Biology, Science, Biological cultures, Organisms, Colon, Cell Staining, Medicine and Health Sciences, Probiotics
69 references, page 1 of 5

1 Rafter J. The effects of probiotics on colon cancer development. Nutr Res Rev. 2004;17: 277–284. doi: 10.1079/NRR200484 19079931 [PubMed]

2 Marco ML, Pavan S, Kleerebezem M. Towards understanding molecular modes of probiotic action. Curr Opin Biotechnol. 2006;17(2): 204–210. 16510275 [PubMed]

3 Zhu Y, Michelle Luo T, Jobin C, Young HA. Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett. 2011;309(2): 119–127. doi: 10.1016/j.canlet.2011.06.004 21741763 [OpenAIRE] [PubMed]

4 Walsh CJ, Guinane CM, O’Toole PW, Cotter PD. Beneficial modulation of the gut microbiota. FEBS Lett. 2014;588(22): 4120–4130. doi: 10.1016/j.febslet.2014.03.035 24681100 [PubMed]

5 Zhong L, Zhang X, Covasa M. Emerging roles of lactic aci d bacteria in protection against colorectal cancer. World J Gastroenterol. 2014;20(24):7878–7886. doi: 10.3748/wjg.v20.i24.7878 24976724 [OpenAIRE] [PubMed]

6 Rauch M, Lynch SV. Probiotic manipulation of the gastrointestinal microbiota. Gut Microbes. 2010;1(5): 335–338. 21327043 [OpenAIRE] [PubMed]

7 Shida K, Nanno M, Nagata S. Flexible cytokine production by macrophages and T cells in response to probiotic bacteria: a possible mechanism by which probiotics exert multifunctional immune regulatory activities. Gut Microbes. 2011;2(2): 109–114. 21637028 [PubMed]

8 Serban DE. Gastrointestinal cancers: influence of gut microbiota, p robiotics and prebiotics. Cancer Lett. (2014);345(2): 258–270. doi: 10.1016/j.canlet.2013.08.013 23981580 [PubMed]

9 Pagnini C, Corleto VD, Mangoni ML, Pilozzi E, Torre MS, Marchese R, et al Alteration of local microflora and α-defensins hyper-production in colonic adenoma mucosa. J Clin Gastroenterol. 2011;45(7): 602–610. doi: 10.1097/MCG.0b013e31820abf29 21346603 [PubMed]

10 Neish AS. The microbiota and colonic neoplasia. An emerging link?J Clin Gastroenterol. 2011;45(7): 571 doi: 10.1097/MCG.0b013e318219221d 21555952 [PubMed]

11 Clevers H. At the crossroads of inflammation and cancer. Cell. 2004;118: 671–674. 15369667 [OpenAIRE] [PubMed]

12 LeBlanc A, LeBlanc J. Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications. World J Gastroenterol. 2014;20(33): 16518–16528.25469019 [OpenAIRE] [PubMed]

13 Oelschlaeger TA. Mechanisms of probiotic actions—A review. Int J Med Microbiol. 2010;300(1): 57–62. doi: 10.1016/j.ijmm.2009.08.005 19783474 [PubMed]

14 Tsilingiri K, Res cigno M. Postbiotics: what else?Benef Microbes. 2013;4(1): 101–107. doi: 10.3920/BM2012.0046 23271068 [OpenAIRE] [PubMed]

15 Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, et al Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011;121(6): 2242–2253. doi: 10.1172/JCI44031 21606592 [OpenAIRE] [PubMed]

69 references, page 1 of 5
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publication . Article . 2016

Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells

Angeliki Tiptiri-Kourpeti; Katerina Spyridopoulou; Valentina Santarmaki; Georgios Aindelis; Evgenia Tompoulidou; Eleftheria E Lamprianidou; Georgia Saxami; Petros Ypsilantis; Evangeli S Lampri; Constantinos Simopoulos; ...