Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175

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Chitnis, Chetan E. ; Mukherjee, Paushali ; Mehta, Shantanu ; Yazdani, Syed Shams ; Dhawan, Shikha ; Shakri, Ahmad Rushdi ; Bharadwaj, Rukmini ; Gupta, Puneet Kumar ; Hans, Dhiraj ; Mazumdar, Suman ; Singh, Bijender ; Kumar, Sanjeev ; Pandey, Gaurav ; Parulekar, Varsha ; Imbault, Nathalie ; Shivyogi, Preethi ; Godbole, Girish ; Mohan, Krishna ; Leroy, Odile ; Singh, Kavita ; Chauhan, Virander S. (2015)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 10, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0117820, pmc: PMC4415778
  • Subject: Q | R | Research Article | Science | Medicine
    mesheuropmc: parasitic diseases

Background A phase I randomised, controlled, single blind, dose escalation trial was conducted to evaluate safety and immunogenicity of JAIVAC-1, a recombinant blood stage vaccine candidate against Plasmodium falciparum malaria, composed of a physical mixture of two rec... View more
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