Hypoxia Activates a Ca-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes

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Vandorpe, David H.; Xu, Chang; Shmukler, Boris E.; Otterbein, Leo E.; Trudel, Marie; Sachs, Frederick; Gottlieb, Philip A.; Brugnara, Carlo; Alper, Seth L.;

Background: Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca2+] ([Ca2+]i) and subsequent activation of KCa 3.1. The resulting erythrocyte volume decrease elevates intracel... View more