Pertinence et validations préclinique et clinique du modèle spontané canin de mélanome dans le développement thérapeutique en oncologie

Doctoral thesis French OPEN
Segaoula , Zacharie;
  • Publisher: HAL CCSD
  • Subject: Mélanome | Melanoma | Canine model | Modèle chien | Cancer | Immune escape | Modèles spontanés | Spontaneous tumor model | [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology | Immunoéchappement

Pharmaceutical development is a long and fastidious process. In fact, each drug candidate has to meet with a certain safety criteria list, pharmacokinetic and pharmacodynamics profiles need to be determined prior to first use in humans and market approval.For years, the... View more
  • References (146)
    146 references, page 1 of 15

    Khanna, C., Lindblad-Toh, K., Vail, D., London, C., Bergman, P., Barber, L., Breen, M., Kitchell, B., McNeil, E., Modiano, J.F., et al. (2006). The dog as a cancer model.

    Nat Biotech 24, 1065-1066.

    Khanna, C. (2008). Novel targets with potential therapeutic applications in osteosarcoma. Curr Oncol Rep 10, 350-358.

    Khanna, C., and Gordon, I. (2009). Catching Cancer by the Tail: New Perspectives on the Use of Kinase Inhibitors. Clin Cancer Res 15, 3645-3647.

    Khanna, C., Fan, T.M., Gorlick, R., Helman, L.J., Kleinerman, E.S., Adamson, P.C., Houghton, P.J., Tap, W.D., Welch, D.R., Steeg, P.S., et al. (2014). Toward a drug development path that targets metastatic progression in osteosarcoma. Clin. Cancer Res.

    Kim, H.-J., and Cantor, H. (2014). The Path to Reactivation of Antitumor Immunity and Checkpoint Immunotherapy. Cancer Immunology Research 2, 926-936.

    Kim, M., Cooper, D.D., Hayes, S.F., and Spangrude, G.J. (1998). Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux. Blood 91, 4106-4117.

    Koenig, A., Bianco, S.R., Fosmire, S., Wojcieszyn, J., and Modiano, J.F. (2002).

    Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma. Vet. Pathol. 39, 458-472.

    Kola I, Landis J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov ; 3 : 711-5.

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