publication . Article . 2004

Variation in alternative splicing across human tissues

Yeo, Gene; Holste, Dirk; Kreiman, Gabriel; Burge, Christopher B;
Open Access English
  • Published: 01 Sep 2004 Journal: Genome Biology, volume 5, issue 10, pages R74-R74 (issn: 1465-6906, eissn: 1465-6914, Copyright policy)
  • Publisher: BioMed Central
Abstract
Background: Alternative pre-mRNA splicing (AS) is widely used by higher eukaryotes to generate different protein isoforms in specific cell or tissue types. To compare AS events across human tissues, we analyzed the splicing patterns of genomically aligned expressed sequence tags (ESTs) derived from libraries of cDNAs from different tissues. Results: Controlling for differences in EST coverage among tissues, we found that the brain and testis had the highest levels of exon skipping. The most pronounced differences between tissues were seen for the frequencies of alternative 3' splice site and alternative 5' splice site usage, which were about 50 to 100% higher in...
Subjects
free text keywords: Research
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publication . Article . 2004

Variation in alternative splicing across human tissues

Yeo, Gene; Holste, Dirk; Kreiman, Gabriel; Burge, Christopher B;