A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

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Porcu, E ; Medici, M ; Pistis, G ; Volpato, CB ; Wilson, SG ; Cappola, AR ; Bos, SD ; Deelen, J ; Den Heijer, M ; Freathy, RM ; Lahti, J ; Liu, C ; Lopez, LM ; Nolte, IM ; O'Connell, JR ; Tanaka, T ; Trompet, S ; Arnold, A ; Bandinelli, S ; Beekman, M ; B?hringer, S ; Brown, SJ ; Buckley, BM ; Camaschella, C ; De Craen, AJ ; Davies, G ; De Visser, MC ; Ford, I ; Forsen, T ; Frayling, TM ... view all 94 authors (2013)
  • Publisher: Public Library of Science
  • Related identifiers: doi: 10.1371/journal.pgen.1003266
  • Subject: FACTOR BINDING PROTEIN-5 | Thyroxine | factor binding protein-S | COMMON VARIATION | Hypothyroidism | Polymorphism, Genetic | Thyroid Gland | 515 Psychology | CLEFT-PALATE | Thyrotropin | 3111 Biomedicine | Hyperthyroidism | Genetics | Polymorphism, Single Nucleotide | Female | Phenotype | HORMONE PATHWAY GENES | EXPRESSION | Signal Transduction | Developmental Biology | Sex Characteristics | SERUM TSH | Genome-Wide Association Study | GROWTH | GENOME-WIDE ASSOCIATION | Humans | Male | R1
    mesheuropmc: endocrine system | endocrine system diseases | hormones, hormone substitutes, and hormone antagonists

<p>Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function ... View more