publication . Article . Other literature type . 2006

T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density

Wedagedera, J. R.; Burroughs, Nigel John;
Open Access English
  • Published: 01 Sep 2006 Journal: Biophysical Journal, volume 91, issue 5, pages 1,604-1,618 (issn: 0006-3495, Copyright policy)
  • Publisher: Biophysical Society
Abstract
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation. We fit our model to four experimentally characterized threshold activation criteria and analyze their specificity and sensitivity: the initial calcium spike, cytotoxicity, immunological synapse formation, and cytokine secretion. Specificity characteristics improve as the time window for detection increases, saturating for time periods on the timescale of downregulation; thus, the calcium spike (30 s) has low specificity but a sensitivity to single-peptide MHC ligands, while...
Subjects
free text keywords: QD, QH301, Biophysics, Biophysical Theory and Modeling
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publication . Article . Other literature type . 2006

T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density

Wedagedera, J. R.; Burroughs, Nigel John;