Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying

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Szekalska, Marta; Wróblewska, Magdalena; Sosnowska, Katarzyna; Winnicka, Katarzyna;
  • Publisher: Hindawi Publishing Corporation
  • Journal: International Journal of Polymer Science (issn: 1687-9422, eissn: 1687-9430)
  • Related identifiers: doi: 10.1155/2016/8635408
  • Subject: TP1-1185 | Chemical technology | Article Subject

Alginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug in the stomach. Nine formulations (F1–F9) with various drug : polymer ratio (1 : 2, 1 : 1, and 2 : 1) and different sodium alginate con... View more
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