A Bicistronic DNA Vaccine Containing Gene of FMDV and Bovine IFN-a Can Prime Humoral and Cellular Immune Responses of Guinea Pigs

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GUO, Huichen; SUN, Shiqi; MA, Jiangtao; LIU, Zaixin; LIU, Xiangtao; XIE, Qingge;
  • Publisher: TUBITAK
  • Journal: issn: 1300-0128, eissn: 1303-6181
  • Publisher copyright policies & self-archiving
  • Subject: Foot-and-mouth disease virus, DNA vaccine, aurintricarboxylic acid, IFN-a, Bicistron expression vector
    mesheuropmc: biochemical phenomena, metabolism, and nutrition | viruses | virus diseases | animal diseases

The study was conducted to evaluate the immunogenicity and protective efficacy of a DNA vaccine against foot-and-mouth disease virus (FMDV). Genes encoding the P1, 2A, 3C of FMDV O/China99 and bovine IFN-a were cloned into pcDNA3.1 (+) expression vector under CMV promot... View more
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