EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT.

Article English OPEN
Kumari Sonal Choudhary; Neha Rohatgi; Skarphedinn Halldorsson; Eirikur Briem; Thorarinn Gudjonsson; Steinn Gudmundsson; Ottar Rolfsson;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Computational Biology,volume 12,issue 6 (issn: 1553-734X, eissn: 1553-7358)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pcbi.1004924, pmc: PMC4890760
  • Subject: Computational Biology | Research Article | Cell Physiology | Anatomy | Genetics | Biological Tissue | Genome Analysis | Genomics | Cell Metabolism | Metabolic Pathways | Cellular Types | Biology and Life Sciences | Metabolic Networks | Computer and Information Sciences | Signal transduction | Genetic Networks | Signaling Networks | Epithelial Cells | Animal Cells | QH301-705.5 | Cell Biology | Cell signaling | EGFR signaling | Biochemistry | Network Analysis | Metabolism | Epithelium | Medicine and Health Sciences | Gene Expression | Biology (General)

Epithelial to mesenchymal transition (EMT) is an important event during development and cancer metastasis. There is limited understanding of the metabolic alterations that give rise to and take place during EMT. Dysregulation of signalling pathways that impact metabolis... View more
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