The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor

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Sánchez, Alejandro ; Espinosa, Patricia ; García, Teresa ; Mancilla, Raúl (2012)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Clinical and Developmental Immunology, volume 2,012 (issn: 1740-2522, eissn: 1740-2530)
  • Related identifiers: doi: 10.1155/2012/950503, pmc: PMC3536062
  • Subject: RC581-607 | Research Article | Immunologic diseases. Allergy | Article Subject

We describe the association of caspase-dependent and caspase-independent mechanisms in macrophage apoptosis induced by LpqH, a 19 kDa Mycobacterium tuberculosis lipoprotein. LpqH triggered TLR2 activation, with upregulation of death receptors and ligands, which was foll... View more
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