The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor
- Publisher: Hindawi Publishing Corporation
Clinical and Developmental Immunology,
(issn: 1740-2522, eissn: 1740-2530)
RC581-607 | Research Article | Immunologic diseases. Allergy | Article Subject
We describe the association of caspase-dependent and caspase-independent mechanisms in macrophage apoptosis induced by LpqH, a 19 kDa Mycobacterium tuberculosis lipoprotein. LpqH triggered TLR2 activation, with upregulation of death receptors and ligands, which was foll...